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The typical American diet is loaded with foods that contain arachidonic acid (like egg yolk, red meat, poultry, and dairy products) or stimulate the production of excess arachidonic acid in the body (foods rich in high-glycemic carbo-hydrates, saturated fats, and omega-6 fatty acids).
Scientific studies show that excess arachidonic acid increases levels of the 5-lipoxygenase (5-LOX) enzyme, which can induce undesirable effects in cells. This culminates in the excess accumulation of leukotriene B4, a pro-inflammatory compound that attacks the joints, the arterial wall, and other tissues.
In India, extracts from the Boswellia plant have been used for centuries as fluid-balancing agents.65 Recent human studies have confirmed that a specific Boswellia extract known as AKBA (3-O-acetyl-11-keto-ß-boswellic acid) selectively inhibits 5-LOX.66 Unlike other boswellic acids that only partially inhibit 5-LOX,66,67 AKBA binds directly to 5-LOX, effectively suppressing its pro-inflammatory activity. A recent study indicated that 5-LOXIN® may exert its beneficial effects by controlling inflammatory responses through reducing pro-inflammatory modulators, and it may improve joint health by reducing the enzymatic degradation of cartilage. A 90-day, double-blind, randomized, placebo-controlled study demonstrated 5-LOXIN® reduces joint discomfort and improves physical functioning significantly in human subjects.68
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