Air Defense Immune Booster Facts
LIKELY USERS:
People seeking to support optimal immune function and respiratory health1-13*
KEY INGREDIENTS:
• PARACTIN®, a patented extract of Andrographis paniculata
• ImmunEnhancer™ AG, Elderberry, Echinacea, and Astragalus herbal extracts
• Olive Leaf Extract
• Antioxidants and amino acids
“STRUCTURE/FUNCTION” STATEMENTS*:
NOW Air Defense™ is a blend of vitamins, minerals, herbs and amino acids that support optimal immune function and respiratory health; the Vitamins, Minerals, and Amino Acids present in NOW Air Defense work together with our herbal blend to support healthy immune function seasonally and year-round.1-13
Non-clinical studies have shown that PARACTIN® helps to support healthy and balanced immune response.3
ImmunEnhancer™ AG (providing Arabinogalactans from the larch tree), Elderberry (10:1 concentrated extract from the fruit), Echinacea (root extract), and Astragalus (root extract containing 70% polysaccharides) have also been included for their immune supporting properties; Olive Leaf Extract has been added to help to maintain healthy respiratory function.1, 2, 4-8, 10-13
Immune Booster1-13; Resistance During Seasonal Changes8, 12; Maintain Healthy Respiratory Function1-13
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:
Olive Leaf Extract has been added to help to maintain healthy respiratory function. The vitamins, minerals, and amino acids present in NOW Air Defense work together with an herbal blend to support healthy immune function during seasonal changes and year-round.*
ADDITIONAL SUPPORTING SCIENCE*:
Review studies have shown that Andrographis paniculata is more effective than placebo in clinical trials.8, 14
PARACTIN® is a patented blend of standardized extract of Andrographis Paniculata containing a blend of Andrographolide, 14-Deoxyandrographolides, and Neoandrographolides. Preliminary research has shown PARACTIN® to stimulate immune response at low doses (25mg to 50mg/day) and promote healthy inflammatory response at high doses (175mg to 250mg/day). The supplier of Paractin® claims that, “this ingredient is clinically proven to reduce COX-2 enzymes by naturally inhibiting Nuclear Factor kappa B (NFkB).”3
SERVING SIZE & HOW TO TAKE IT:
Take two vegetarian Vcaps® one to three times a day, preferably with meals or alternate sources of healthy oils that help you to absorb the fat-soluble constituents of NOW Air Defense™.
Consider taking this formula with:
NOW Immune Renew™, AlliBiotic CF™, or Tru-C BioComplex™
CAUTIONS:
SPECIFIC: People with autoimmune diseases should consult a physician before use of NOW Air Defense™.
GENERAL: Pregnant women, lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This product is not labeled for use by children; please consult a pediatrician before use by a child.
When starting to take any new supplement it is usually best to try one capsule first, rather than immediately taking the maximum number of servings, in order to assess its effects on you. This should help to minimize any unforeseen sensitivities you may have to an ingredient in the product. Do not exceed the maximum number of servings shown on a product label (unless specifically directed to do so by your physician).
Neil E. Levin, CCN, DANLA, Board-Certified Clinical Nutritionist with Diplomate in Advanced Nutritional Laboratory Assessment, 11/06/06
References:
1 Yoshida Y, Wang MQ, Liu JN, Shan BE, Yamashita U (1997) Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int J Immunopharmacol 19(7):359-370.
2 Youdim KA, Martin A, Joseph JA (2000) Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 29(1):51-60.
3 Paractin® website
4 Zakay-Rones A, Thom E, Wollan T, Wadstein J (2004) Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res 32(2):132-140.
5 Zakay-Rones A, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M 1995) Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med 1(4):361-369.
6 Manganelli REU, Zaccaro L, Tomei PE. (2005) Antiviral activity in vitro of Urtica dioica L., Parietaria Diffusa M. et K. and Sambucus nigra L. J Ethnopharmacol 98(3):323-327.
7 Barak V, Halperin T, Kalickman I. (2001) The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 12(2):290-6.
8 Poolsup N, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther. 2004 Feb;29(1):37-45.
9 Cunningham-Rundles S, McNeeley DF, Moon A. Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol. 2005 Jun;115(6):1119-28; quiz 1129. Review.
10 Choi EM, Kim AJ, Kim YO, Hwang JK. Immunomodulating activity of arabinogalactan and fucoidan in vitro. J Med Food. 2005 Winter;8(4):446-53.
11 Currier NL, Lejtenyi D, Miller SC. Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53.
12 Zaslaver M, Offer S, Kerem Z, Stark AH, Weller JI, Eliraz A, Madar Z. Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells. J Agric Food Chem. 2005 Dec 28;53(26):9934-9.
13 "Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther. 2006 Feb;28(2):174-83. Review.
14 Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med. 2004 Apr;70(4):293-8. Review. PMID: 15095142.
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