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Serrapeptase is a proteolytic enzyme isolated from the non-pathogenic bacteria Serratia species found in the digestive tract of the Japanese silkworm. Serrapeptase has been used as a nutritional supplement in Europe and Asia for nearly three decades. Each enteric-coated vegetarian capsule of Best Serrapeptase contains pure serrapeptase designed for optimal absorption in the intestinal tract.
Note: Doctor’s Best Serrapeptase contains 40,000 Serratiopeptidase units, which refers to the enzyme activity level. Enzymes, like Serrapeptase, are not measured in mg, but in an unassociated measure of units. Doctor’s Best Serrapeptase has 40,000 Serratiopeptidase (units) of activity per capsule. This is a very high amount of activity.
Serrapeptase has been widely used in Japan and Europe for decades. Dr. Hans Nieper, a legendary medical doctor known for his extensive use of proteolytic enzymes, named it the “Miracle Enzyme” because of its unique abilities. Serrapeptase is made by the bacteria Serratia E15 found in the digestive tract of silkworms, which harness the serrapeptase enzyme to break down food and the walls of their silk cocoons as they emerge in their moth state.
Proteolytic enzymes function in the body to digest and break down proteins into their amino acid components. When taken as supplements away from meals, these enzymes enter the bloodstream and are available to facilitate chemical reactions throughout the body.1 They work in part by helping to support a healthy inflammatory response and by modulating the immune system. Serrapeptase may facilitate a more balanced release of bradykinin (presumably downplaying bradykinin receptor B1 activity).2, 3
In terms of strength, serrapeptase recently demonstrated a greater ability to promote a balanced inflammatory response compared with two powerful proteolytic enzymes secreted by the human pancreas, chymotrypsin and trypsin.4
Serrapeptase has been used for years in Japan for supporting healthy sinus function. Studies thus far suggest that serrapeptase is a promising, safe, and useful supplement to help support the immune system and promote favorable viscosity of nasal mucus.5, 6 In one controlled and randomized open-label study, researchers observed the effects of 30 mg/day (equivalent to ~ 60,000 units of activity) of serrapeptase on the sputum of 29 individuals. After 4 weeks, those taking serrapeptase had significantly less morning sputum, and it was thinner and less elastic in nature compared to those taking placebo. The serrapeptase group also had fewer neutrophils in their sputum, signifying a more balanced immune response.7
Doctor’s Best discloses the potency details of Serrapeptase so you know exactly what you're getting. Enzyme strength is measured in terms of activity. Enzymes may be present, but unless they are functional, they will not be useful. Instead of being measured by weight (such as in milligrams), the important measurement with enzymes is the activity and potency of the enzyme. A product label should list enzyme strength in standard activity units rather than by weight. To meet your individual needs, there are two levels of potency to choose from with Best Serrapeptase enteric-coated vegetarian capsules—either 40,000 or 120,000 Serratiopeptidase units.
1.Tachibana, M., et al., A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica, 1984. 3(8): p. 526-30.
2.Mecikoglu, M., et al., The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection. J Bone Joint Surg Am, 2006. 88(6): p. 1208-14.
3.Mazzone, A., et al., Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res, 1990. 18(5): p. 379-88.
4.Viswanatha Swamy, A.H. and P.A. Patil, Effect of some clinically used proteolytic enzymes on inflammation in rats. Indian J Pharm Sci, 2008. 70(1): p. 114-7.
5.Majima, Y., et al., Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am Rev Respir Dis, 1990. 141(1): p. 79-83.
6.Majima, Y., et al., The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol, 1988. 244(6): p. 355-9.
7.Nakamura, S., et al., Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology, 2003. 8(3): p. 316-20.
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Prices are subject to change at anytime and without notice. The majority of the product information has been reprinted from the manufacturer.