CLA Extreme Fact Sheet
Neil E. Levin, CCN, DANLA
People wanting to control body fat; People wanting to increase their body’s lean mass (muscle tissue); People wanting an oil that helps to reduce pro-inflammatory body chemicals; Those wanting to prevent undesirable cellular changes through diet.
CLA from safflower oil, L-Carnitine amino acid, Guarana Seed extract (20% naturally occurring caffeine), Green Tea extract (40% polyphenols), Chromium Picolinate.
MAIN PRODUCT FEATURES:
Conjugated Linoleic Acid (CLA) is a derivative of linoleic acid, an essential fatty acid. The softgel is formulated with CLA (derived from safflower oil), Green Tea extract (polyphenols), Guarana extract (caffeine), L-Carnitine, and Chromium (III) Picolinate for synergistic effects of reducing body fat and increasing lean muscle mass.
OTHER IMPORTANT ISSUES:
One study, titled "Efficacy and Safety of One-Year Supplementation with Conjugated linoleic Acid in Moderate Overweight," found that compared to placebo, CLA-supplemented subjects had Body Fat Mass index scores averaging 9% lower than the placebo group and had Lean Body Mass results showing lean muscle mass averaging 2% more than the placebo group. Analyses of blood tests showed no side effects over this one-year period. CLA plus Guarana reportedly reduces the size and number of fat cells in another report. CLA may also reduce insulin resistance and prevent undesirable cellular changes.
AMOUNT and HOW TO USE:
One to five capsules a day, preferably with meals.
Alpha Lipoic Acid, Vitamin E, other Antioxidants
CLA may reduce insulin resistance, so people on blood sugar medications may not need as much of their drugs. Use with caution to avoid an overdose of your blood sugar medication when using this oil. Please notify your physician about your supplement use if you are using any drugs!
Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am. J. Clin. Nutr. 79(6):1118–1125 (2004).
Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams CM, Calder PC, Yaqoob P. Effects of cis-9,trans-11 and trans-1 0,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am. J. Clin. Nutr. 80(6):1626–1633 (2004).
Aminot-Gilchrist DV, Anderson HDI. Insulin resistance-associated cardiovascular disease: potential benefits of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1159S–1163S Suppl. S (2004).
Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui YZ, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127(3):777–791 (2004).
Bergamo P, Luongo D, Rossi M. Conjugated linoleic acid - Mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. Cell Physiol. Biochem. 14(1–2):57–64 (2004).
Bouthegourd JC, Martin JC, Gripois D, Roseau S, Tome D, Even PC. Fat-depleted CLA-treated mice enter torpor after a short period of fasting. Appetite 42(1):91–98 (2004).
Brown JM, Boysen MS, Chung S, Fabiyi O, Morrison RF, Mandrup S, McIntosh MK. Conjugated linoleic acid induces human adipocyte delipidation - Autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J. Biol. Chem. 279(25):26735–26747 (2004).
Cheng WL, Lii CK, Chen HW, Lin TH, Liu KL. Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappa B pathway. J. Agric. Food Chem. 52(1):71–78 (2004).
Choi JS, Jung MH, Park HS, Song JY. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 20(11–12):1008–1017 (2004).
Cortes HN. CLA and body composition: Research shows conjugated linoleic acid can help maintain a healthy balance between lean muscle and body fat. Agro Food Industry Hi Tech 15(2):49–51 (2004).
Dauchy RT, Dauchy EM, Sauer LA, Blask DE, Davidson LK, Krause JA, Lynch DT. Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. Cancer Lett. 209(1):7–15 (2004).
Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med. Sci. Sport Exercise 36(5):814–820 (2004).
Field CJ, Schley PD. Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Am. J. Clin. Nutr. 79(6):1190S-1198S Suppl. S (2004).
Hirao A, Yamasaki M, Chujo H, Koyanagi N, Kanouchi H, Yasuda S, Matsuo A, Nishida E, Rikimaru T, Tsujita E, Shimada M, Maehara Y, Tachibana H, Yamada K. Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats. J. Nutr. Sci. Vitaminol. 50(1):9–12 (2004).
Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 323(2):679–684 (2004).
Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions. Lipids 39(7):611–616 (2004).
Lamarche B, Desroches S. Metabolic syndrome and effects of conjugated linoleic acid in obesity and lipoprotein disorders: the Quebec experience. Am. J. Clin. Nutr. 79(6):1149S–1152S Suppl. S (2004).
Malpuech-Brugere C, Verboeket-van de Venne WPHG, Mensink RP, Arnal MA, Morio B, Brandolini M, Saebo A, Lassel TS, Chardigny JM, Sebedio JL, Beaufrere B. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Res. 12(4):591–598 (2004).
McCann SE, Ip C, Ip MM, McGuire MK, Muti P, Edge SB, Trevisan M, Freudenheim JL. Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB study). Cancer Epidemiol. Biomarkers Prevent. 13(9):1480–1484 (2004).
Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am. J. Clin. Nutr. 80(4):887–895 (2004).
Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KWJ. Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis 25(7):1185–1191 (2004).
O'Shea M. Clarinol(TM) CLA (Conjugated Linoleic Acid): the weight of evidence supports a safe and efficacious product for weight management. Agro Food Industry Hi-Tech 15(4):24–26 (2004).
O'Shea M, Bassaganya-Riera J, Mohede ICM, Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 79(6):1199S–1206S Suppl. S (2004).
Rainer L, Heiss CJ. Conjugated linoleic acid: Health implications and effects on body composition. J. Am. Dietetic Assoc. 104(6):963–968 (2004).