Essential Structural Support for Hair, Skin, Nails, Tendons, Ligaments and Bones*
There are a number of different types of collagen; the most prevalent two in the human body are types I and III. In fact, type I collagen is the most abundant protein in the human body—it is present in almost every type of tissue.1 Bone contains almost exclusively type I collagen. The collagen network in bone confers structural strength to bone tissue and prevents bone fragility. Deficient or defective collagen production, as can occur with aging, is a risk factor for fractures and other bone deformities.2
Type I collagen is also the major protein found in skin connective tissue where it is responsible for providing skin with its tensile strength and resiliency.3 Type III collagen is found at high levels in cardiovascular tissue and also in newly developing skin. It is essential for the proper development of the cardiovascular system and skin tissue. Types I and III collagen are often found together in the same tissues, as each form complements the structural integrity of the other.
Collagen and Normal Aging
Collagen synthesis is a continuous process throughout life. Collagen is essential for growth and repair, and is also produced during the process of wound healing. Rejuvenation and renewal of every tissue throughout the body requires the production of newly synthesized collagen. However, this process can become less efficient as we age, leading to decreased renewal of old tissue.5 This is manifested internally as a lessened efficiency of organ and tissue function. However, the most obvious manifestation of this process occurs externally. The most visible tissue in the body, and the most obvious place to observe the effects of aging, is the skin. As the skin ages, the levels of type I and III collagen, as well as elastin, decrease in the dermis, resulting in the loss of elasticity.3 This results in the appearance of wrinkles, fine lines and an aged look, as well as various skin blemishes and discoloration. The rate at which this occurs depends upon many factors including genetics, metabolic processes, hormonal changes and environmental exposures, such as to UV radiation from the sun or smoking tobacco (both of which can lead to increased break down of collagen in the skin and/or decreased synthesis of new collagen).6,7
Oxidative stress is thought to play a large role in the aging process as well. In general, while we are youthful, our body has the ability to combat the internal and external effects of oxidative stress more efficiently. However, as we age, and due to the genetic, metabolic and environmental changes mentioned above, often the amount of free radical production outpaces the antioxidant defenses of our body’s organs and tissues.
Since the body has become less efficient at dealing with the various stressors it encounters on a daily basis, it is even more critical to help it by providing the antioxidants and structural building blocks it needs to continually rejuvenate itself. Of course, a healthy diet that is rich in fruits and vegetables, as well as targeted nutritional supplementation, provide a wide range of antioxidants that the body can use to bolster its defense mechanisms. Furthermore, supplementing with Best Collagen can benefit the body by providing structural support.
Best Collagen Types 1 & 3 contains the necessary building blocks for collagen renewal and the cofactors that enhance tissue strength and integrity. Replenishing the structural building blocks and antioxidants on a consistent basis can lead to healthy, vibrant and youthful tissue and organ function. Efficient collagen renewal also leads to strong, healthy bones. Outwardly, this manifests as supple skin with a decrease in wrinkles and blemishes, and an increase in strength and elasticity.
1.Jensen LT, Høst NB. Collagen: scaffold for repair or execution. Cardiovasc Res. 1997 Mar;33(3):535-9.
2.Vashishth D. The role of the collagen matrix in skeletal fragility. Curr Osteoporos Rep. 2007 Jun;5(2):62-6. Click here for study.
3.Callaghan TM, Wilhelm KP. A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part I: Cellular and molecular perspectives of skin ageing. Int J Cosmet Sci. 2008 Oct;30(5):313-22. Click here for study.
4.Murad S, Grove D, Lindberg KA, Reynolds G, Sivarajah A, Pinnell SR. Regulation of collagen synthesis by ascorbic acid. Proc Natl Acad Sci U S A. 1981 May;78(5):2879-82. Click here for study.
5.Sørensen LT. Effect of lifestyle, gender and age on collagen formation and degradation. Hernia. 2006 Dec;10(6):456-61. Click here for study.
6.Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie G, Cho KH, Kim KH, Park KC, Eun HC. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol. 2001 Nov;117(5):1218-24. Click here for study.
7.Yin L, Morita A, Tsuji T. Tobacco smoke extract induces age-related changes due to modulation of TGF-beta. Exp Dermatol. 2003;12 Suppl 2:51-6. Click here for study.