Probiotic & Prebiotic (Synbiotic) Supplement! Dr. Ohhira.s Probiotics Original Formula is a totally vegan, dairy and bovine free, non-GMO, hypoallergenic, dietary supplement that helps establish and maintain the healthy micro flora in the GI tract, enhances the body's natural immune system and encourages systemic good health.* Regular use supports the elimination of toxic digestive byproducts and the maintenance of optimal pH of the colon.* Each synbiotic supplement contains biogenically active fermented paste developed after decades of scientific research by Dr. Iichiroh Ohhira and his Japanese research team.
• Biogenically Active Ingredients
• Supports Digestive Functions
• Delivered in Culture Medium
• Not Freeze-Dried
• No SBO.s
• E. faecalis TH10 Strain of LAB & 11 Additional Strains Used in Fermentation and maturation
• Multi Year, Natural Temperature, Fermentation Process Enhances Product Viability and Strength
• Naturally Developed Organic Acids, Vitamins, Minerals & Amino Acids
• Formulated by Iichiroh Ohhira, Ph.D. . Recipient of Japan Science Recognitions and Gusi Award (2004)
• Japan Dairy Science Association Award (1991)
• University-Based Research
• Certified Lab Analysis
• Soft Enteric-Coated Vegetable Capsule Ensures Delivery of Ingredients Thru Harsh Acids to Colon
• Refrigeration Not Required
• 3-Year Shelf Life
• Bovine Free
• Used by Physicians & Clinical Nutritionists
• Endorsed by Dr. Ann Louise Gittleman
A High-Technology Adventure: The Development of Dr. Ohhira's Probiotics Original Formula
This is the story of how Iichiroh Ohhira, Ph.D. and a team of research scientists from Okayama University in Japan researched, formulated and commercialized a unique probiotic product that combines ancient Japanese fermentation skills with 21st Century technology. Dr. Ohhira.s Probiotics Original Formula is a totally vegetarian, bovine-free, non-GMO, hypoallergenic, dietary supplement that restores and maintains the healthy microflora in the GI tract, enhances the body.s natural immune system and encourages systemic good health! Dr. Ohhira.s Probiotics Original Formula has made an evolutionary leap in probiotic science. Not only is the GI tract.s delicate micro flora reestablished but immune functions are enhanced and regular bowel movements are supported. Toxic digestive byproducts are eliminated and optimal pH of the colon is maintained with regular use. Each capsule contains biologically active fermented paste formulated after decades of scientific research by Dr. Ohhira and his Japanese research team.
INTRODUCTION Within every human being is a flourishing, living colony of approximately four pounds of bacteria. Most of these bacteria reside in the human digestive tract although some live elsewhere (i.e., oral cavity, throat, etc.). Absent a sufficient number of friendly lactic acid bacteria, known as "probiotics," human life could not exist. When a human fails to maintain a sufficient number of good bacteria in the body, disease usually occurs and death often follows. Life on planet Earth requires adequate colonies of friendly lactic acid bacteria to survive, regardless of whether you.re a human, dog, bird, tree, fish or other life form.
It is extremely important to cultivate and maintain a healthy colony of good bacteria in the GI tract--a colony that is comprised of several strains of lactic acid bacteria. The microflora in the digestive tract should be composed of at least 85 percent friendly bacteria and not more than 15 percent harmful bacteria. The regular consumption of Dr. Ohhira.s Probiotics Original Formula, a high quality probiotic product containing twelve strains of viable lactic acid bacteria and a wealth of micronutrient byproducts, will enhance a person’s efforts to establish and maintain the healthy microflora colony in the GI tract.
THE DAWN OF THE 21ST CENTURY The technological revolution of the 20th Century launched discoveries and wonders that have forged the highest standard of living known to mankind. Within the health industry alone, many deadly diseases have been eradicated and scientists continue to announce new breakthroughs that lead to improved health. However, many antagonists to good health continue to thrive and when left unchallenged are seriously able to weaken the immune system.
Half way into the first decade of the 21st Century, humans are confronted with a hustle-and-bustle lifestyle unimaginable twenty years ago. While enjoying the highest standard of living ever known to man, humans have been dubiously rewarded with increased stress and tension, exposure to viruses, yeasts, bacteria and life-threatening environmental pollutants previously unfamiliar to mankind. Unintended consequences of the technological revolution have adversely modified human health.
For example, antibiotics, one of the wonder drugs of the 20th Century, have helped conquer many diseases that previously resulted in death or disablement. We now know, however, that antibiotics have limitations and their frequent use and misuse often lead to ill health. There are a growing number of microorganisms that have developed partial or total resistance to some antibiotics. Further, wide-spectrum antibiotics can.t distinguish between the "bad" and "good" bacteria and they kill both the good along with the bad. This indiscriminate killing of bacteria may be the worse side-effect of antibiotics. Clearly, antibiotics properly administered are useful but their use kills the good bacteria and weakens the immune system.
DR. OHHIRA’S STUDY OF HUMAN BACTERIA Iichiroh Ohhira, Ph.D., who is acclaimed for his development of Dr. Ohhira.s Probiotics Original Formula, is a renowned, award-winning microbiologist from Okayama University in Japan. He has dedicated his life to the study of lactic acid bacteria and to improving human health by ensuring adequate colonies of friendly bacteria in the colon.
Dr. Ohhira was first exposed to the wonders of lactic acid bacteria in Malaysia. After scrutinizing the Malaysian eating habits, he surmised that it must be the fermented foods they ate that led to their good health and longevity.
In an effort to identify and isolate the beneficial ingredients of the fermented foods consumed in Asia, Dr. Ohhira researched these foods for more than two decades. Because of his efforts, and those of his team of research scientists, he confirmed and built upon earlier scientific findings that, ".there are two types of human bacteria--the .good. or friendly types and the .bad. or harmful types." He agreed that each human requires 85 percent of the good bacteria to nourish the body and keep it healthy. He discovered that although there are more than several hundred kinds of lactic acid bacteria, only about 20 are actually beneficial to human health.
Dr. Ohhira learned that the human body, although created with the proper ratio of good to bad bacteria, frequently alters the ratio of bacteria because of today’s modern lifestyle. The unintended side-effect of wide-spectrum antibiotics permits bad microorganisms to invade the GI tract and multiply in such high numbers that the delicate balance between the good and bad bacteria is disturbed. The altering of this delicate balance, known as dysbiosis, also is caused by the consumption of second-hand antibiotics present in meat, poultry and dairy products, use of oral contraceptives and steroids, exposure to radiation through x-rays and radiation therapies, excessive consumption of chlorinated water, eating of refined sugars and other refined foods, poor digestion, poor elimination of waste, stress and tension, an unhealthy diet, etc.
Scientists have determined that when the delicate balance between good and bad bacteria is adversely altered, the body may become overloaded with toxins and disease. According to many imminent health care professionals, toxins emanating from the GI tract are often the cause of chronic diseases and illnesses.
Scientists have determined that there are many negative health effects that stem from the loss of probiotics, including the lack of recirculation of female hormones such as estrogen, and the overgrowth of detrimental, disease-causing bacteria and yeasts such as Candida albicans, Staphylococcus aureus, E. coli , Yersinia enterocolitica, Clostridium dificile, etc.
The presence of too few probiotics encourages the production of endotoxins in the GI tract, which contributes to lupus erythematosus, pancreatitis, psoriasis and other skin conditions. A shortage of probiotics allows partially digested proteins to enter the bloodstream contributing to eczema, nervous system disorders, rheumatoid arthritis, and a variety of other immune system disorders.
A loss of probiotics and the subsequent appearance of detrimental microorganisms in the colon contribute to GI tract problems such as leaky bowel syndrome, Crohn.s disease, ulcerative colitis, spastic colon or irritable bowel syndrome (IBS), etc. Specific strains of detrimental bacteria are known to cause severe health problems. For example, E. coli , often found on unwashed produce and raw meat, may lead to problems with insulin and blood sugar function. Yersinia enterocolitica produces substances that cause the overproduction of the thyroid hormone. This harmful bacterium also contributes to autoimmune diseases.
PROBIOTICS: THE GOOD BACTERIA After more than 20 years of research, Dr. Ohhira has scientifically concluded that good health prevails when the friendly bacteria in the GI tract are properly colonized and ill health too often is the result of a colony of bad microorganisms. Western scientists are now confirming many of his early research discoveries.
Based on Dr. Ohhira’s research, it would then seem to be a logical conclusion that simply providing large numbers of good bacteria to sick and unhealthy persons should lead to dramatic improvement in their unhealthy condition. Unfortunately, that conclusion is wrong! Why?
Dr. Ohhira has found that the consumption and short-term presence of good bacteria alone does not lead to good health unless the digestive tract is free from the continual onslaught of harmful microorganisms including yeasts, viruses and bad bacteria. He strongly believes that the benefits of using probiotics can only be realized when the proper colonic pH is reestablished. Simply introducing friendly bacteria in large numbers will not resolve the situation because an unfavorable colonic condition has already been created and such a condition is conducive to the proliferation of harmful microorganisms.
Dr. Ohhira understands the foundation of good health and knows how to alter the microflora in the colon so humans can ensure a healthy immune system and enjoy good health. He has concluded that an important approach to good health is to remove the harmful bacteria from the colon by creating an exclusive condition (i.e., an acidic pH) that is only conducive for the proliferation of friendly bacteria. He believes the eradication of the harmful bacteria in a natural manner is preferable when seeking to reestablish and maintain good health.
The colonization of the friendly bacteria in the GI tract begins at birth. Dr. Ohhira observed that a high percentage of children nourished on mother’s milk enjoy good health and a stronger immune system when compared to bottle-fed infants. He also observed that these children acquired a larger number of friendly strains of bifidobacteria when compared to bottle-fed children who had few or none at all. Studies by scientists confirm that cesarean-section babies frequently have lesser amounts of friendly bacteria than do normal birth babies, and in some instances, these c-section babies lack certain strains of the good bacteria entirely. This finding has led scientists to surmise that certain good bacteria may be introduced to the infant as it passes through the mother’s birth canal.
The acidic colon condition of breast-fed babies remained within a constant range of pH 5.5 to 6.5. Studies have demonstrated that the presence of sufficient levels of lactic acid in the colon of infants creates this acidic condition. Dr. Ohhira noted that it is mainly the organic acids, produced by the lactic acid bacteria present in the colon, that prevent the survival of harmful bacteria in the baby’s intestinal tract. This inherent condition forms the first line of defense for the baby against illness.
DR. OHHIRA’S PROBIOTIC PRODUCT As Dr. Ohhira delved further into the science of good health, he discovered that certain naturally fermented foods consumed in Asia are a rich source of lactic acid bacteria. After years of studying the known strains of lactic acid bacteria occurring in fermented foods indigenous to Southeast Asia, Dr. Ohhira developed an award-winning probiotic product that recolonizes the microflora in the digestive tract, enhances the immune system and promotes good health--a product that may be several technological generations ahead of other probiotics.
Dr. Ohhira and other scientists have found that the excessive use of antibiotics has led to the creation of new strains of "smart" bacteria that have become resistant to antibiotics. To combat these new harmful invaders, Dr. Ohhira’s team developed a special strain of friendly lactic acid bacteria that was successfully isolated from the Malaysian culinary soybased food--tempeh. This special E. faecalis TH10 strain has been found during in vitro studies to be effective against the most potent antibiotic resistant MRSA (methicillin resistant Staphylococcus aureus) smartbug, as well as E. Coli 0157 (cause of food poisoning), H. pylori (cause of peptic ulcers, morning sickness and migraine headaches), Bacillus cereus (cause of intestinal anthrax), Clostridium dificile and other harmful microorganisms.
The transient, combative TH10 bacteria may be the most important strain of bacteria in Dr. Ohhira’s product because it kills and eliminates harmful bacteria found in the colon and aids in the removal of toxins that were produced in the colon by the bad bacteria. After consumption, the TH10 bacteria reside in the GI tract for an extended period of time where they flourish and coexist with other strains of bacteria, like the important lactobacillus and bifidobacteria strains. The good bacteria aid in the digestion and the absorption of nutrients, while forming a barrier against the invasion of bad bacteria.
The special TH10 strain of bacteria, as well as the eleven other strains of lactic acid bacteria, and the very important micronutrient byproducts, which include naturally developed organic acids, FOS, hydrogen peroxide and bacteriocins, are created during an up to five-year natural-temperature fermentation period. During this entire period, only natural vegetarian ingredients are used.
The proprietary formula of ingredients include at least 92 types of natural products, including special leaves, herbs and fruits, which grow wild in a vast region of the Kibi Highlands and Hiruzen Highlands of the Chugoku district, plus two kinds of seaweed and various organic vegetables. This blend is combined with twelve strains of live lactic acid bacteria, which include the most prominent strain of bacteria possessing the highest proteolytic power in the world. In fact, scientists have established that the TH10 strain of lactic acid bacteria contained only in Dr. Ohhira’s probiotic product is 6.25 times stronger than any other known naturally occurring lactic acid bacteria.
The major ingredients in Dr. Ohhira.s Probiotics Original Formula include.six wild fruits: Chinese matrimony (Lycium Chinese), Wild vine (Vitis coignetiae), Chinese bayberry (Myrica rubra), Mulberry (Morus australis), Wild strawberry (Rubus buergeri ),and Oleaster (Elaeagnus montana); two seaweed: Sea tangle (Laminaria japonica) and Brown seaweed (Hizikia fusiforme); and two herbs: Mugwort (Artemisia montana), Broad-leafed plantain (Plantago asiatica) and mountain spring water. The product is guaranteed to be free of soil-based organisms (SBOs).
During the fermentation process, the creation of at least four important organic acids—acetic, formic, fumaric and lactic— are carefully monitored. Daily inspections are conducted to determine the pH and nutrient levels of the fermentation product and to guard against contamination. Inspections also assure compliance with stringent Japanese good manufacturing practice standards. The Japan Food Research Laboratories, which is authorized by the Japanese Government, analyze the final product. Only when the product accumulates a scientifically preordained level of organic acids is the raw paste ready for encapsulation. The highly regarded Fuji Capsule Company Limited of Japan provides the high-tech encapsulation of the product using a special enteric-coated capsule material developed by Fuji and Dr. Ohhira.
END PRODUCT CONSTITUENTS Dr. Ohhira’s Probiotics Original Formula contains 12 strains of viable lactic acid bacteria, four types of organic acids, ten vitamins, eight minerals, 18 amino acids, naturally occurring fructooligosaccharides (FOS)—a prebiotic nutrient that is important to the health and longevity of LAB—hydrogen peroxide, enzymes and bacteriocins.
TWELVE STRAINS OF LIVE LACTIC ACID BACTERIA 1
• Bifidobacterium breve ss. Breve
• Bifidobacterium infantis ss. Infantis
• Bifidobacterium longum
• Enterococcus faecalis TH10
• Lactobacillus brevis
• Lactobacillus acidophilus
• Lactobacillus bulgaricus
• Lactobacillus casei ss. Casei
• Lactobacillus fermentum
• Lactobacillus helveticus ss. Jugurti
• Lactobacillus plantarum
• Streptococcus thermophilus
FOUR ORGANIC ACIDS
• Lactic Acid
• Fumaric Acid
• Formic Acid
• Acetic Acid
• Biotin .0000467
• Carotene .0001299
• Folic Acid .0000173
• Inositol .2121700
• Niacin .0033774
• Pantothenic acid .0034640
• Riboflavin .0012990
• Thiamin .0001732
• Vitamin B6 .0003723
• Vitamin B12 .0000009
• Calcium .7620800
• Iron .0198747
• Magnesium .0001931
• Manganese 1.1387900
• Phosphorus .7490900
• Potassium 2.3295400
• Sodium 1.4592100
• Zinc .0029270
EIGHTEEN AMINO ACIDS*
• Alanine .0013423
• Arginine .0010825
• Aspartic acid .0037671
• Cystine .0003464
• Glutamic acid .0070579
• Glycine .0009959
• Histidine .0009526
• Isoleucine .0016887
• Leucine .0030743
• Lysine .0014722
• Methionine .0006062
• Phenylalanine .0016454
• Proline .0029011
• Serine .0018619
• Threonine .0015155
• Tryptophan .0003897
• Tyrosine .0009526
• Valine .0020351
1CFU of 1 gram of LAB is 1.3 billion. *Vitamins, minerals and amino acids are trace amounts; values shown as mg/capsule. Ingredient weight per capsule is 0.433. The actual levels of vitamins, minerals and amino acids may vary slightly among batches due to the natural variation of ingredients.
The enteric-coated ensures the integrity and storage stability of its contents by preventing oxidation and product degradation as well as eliminating the need for artificial preservatives and additives. It protects its contents from the corrosive action of harsh stomach acids and ensures the safe arrival of the ingredients to the colon. Because of the enteric-coated capsule, the product remains highly viable with a stable shelf life of three years. Refrigeration is not required at room temperature.
The product is 100 percent natural; most ingredients are harvested in the wild. It is a non-dairy, non-GMO, hypoallergenic, vegetarian formula product. Chemicals, preservatives, artificial additives, coloring agents and animal by-products are never used. Chemical fertilizers, pesticides and herbicides are not permitted. Pure mountain spring water is the only liquid used in the product. It is recommended for infants, children, pregnant or nursing mothers, the elderly and those with compromised immune systems.
PRODUCT’S BENEFITS Each of the probiotic product’s ingredients is readily absorbed and used for various important functions of the human body, thus enhancing proper cellular functions and strengthening the body’s autoimmune system. Among their many benefits, probiotics help manufacture specific vitamins, regulate peristalsis and regular bowel movements, assist immune functions by keeping the colon at a proper pH level, break down and rebuild hormones, and help to normalize cholesterol and triglycerides.
In human trials conducted from 1979 through 1991, 1250 subjects were randomly chosen from a sample of 5,000 persons and studied. The following research findings were reported.
• Improved digestive functions
• Decreased incidence of digestive ailments
• Decreased incidence of stomach ailments
• Decreased incidence of bloating and heartburn
• Improved liver function
• Improved circulatory function
• Improved bowel function
• Decreased incidence of constipation or diarrhea
• Improved joint and muscle function
• Improved resistance to allergies
• Increased nutritional absorption
• Improved vitamin synthesis
• Increased energy
• Decreased presence of yeast infection
• Decreased incidence of various infections
• Decreased incidence of oral cavity infections
• Better lactose tolerance
• Improved sleep functions
• Improved appetite
PARTIAL LIST OF AVAILABLE SCIENTIFIC RESEARCH Antimicrobial Activity Against Methicillin-resistant Staphylococcus aureus in the Culture Broth of Enterococcus faecalis TH10, an Isolate from Malaysian Fermentation Food— Tempeh. Authors: I. Ohhira, Ph.D., T. Tamura, Ph.D., N. Fujii, Ph.D., K. Inagaki, Ph.D., and H. Tanaka, Ph.D. Department of Biological Resources, Faculty of Agriculture, Okayama University, Okayama, Japan. Published in the Japanese Journal of Dairy and Food Sciences, Vol. 45, Number 4 (1996)
In Vitro Efficacy of (Ohhira) Capsules Against Helicobacter pylori . Authors: J. Lambert, Ph.D. and Research Assistant C. Mishra. Gastrointestinal Research Group, Monash University, Department of Medicine, Clayton, Victoria, Australia. Published in the Asia Pacific J Clin Nutr, 5:20-4, (1996)
The Safety of Capsules Containing (Ohhira) Lactic Acid Bacilli. Authors: T. Paraidathathu, Ph.D., and L. S. Hup, Ph.D., Pharmacy Department, Faculty of Allied Health Sciences, University of Malaysia, Kuala Lumpur, Malaysia. Symposium on Oral Recurrent Aphthous Ulcerations: Epidemiology, Clinicopathology and Management, University of Malaysia, Kuala Lumpur, Malaysia (1999)
Inhibitory Effects of (Ohhira) Lactic Acid Bacteria on Some Pathogens Including MRSA. Authors: K. Philip, Ph.D., H. Tanaka, Ph.D., and I. Ohhira, Ph.D., Kuala Lumpur, Malaysia (1998)
The Influences on the VO2 max of Athletes Taking (Ohhira) Lactic Acid Bacteria. Authors: I. Ohhira, Ph.D., M. Kawasaki, Ph.D., N. Araki, Ph.D., K. Inokihara, Ph.D., T. Matsubara, Ph.D., and H. Iwasaki, Ph.D. Research conducted at Kurashiki University of Science and the Arts, Kurashiki, Japan, Research Institution of Okayama Life Science, Okayama, Japan and Sanyo Gakuen University, Okayama, Japan (1997)
Antioxidant Property and Upper Gastrointestinal Tract Conditions as Affected by (Ohhira) Probiotic Capsules. Author: K. Philip, Ph.D., Kuala Lumpur, Malaysia (1997)
Anti-Bacterial Activity of Probiotic Lactic Acid Bacteria Enterococcus faecalis TH10 and Transduction of Human Intestinal Tracts Cohesive Factor to E. faecalis TH10. A scientific research paper prepared by Iichiroh Ohhira, Ph.D. (2000)
The Influences of (Ohhira) Lactic Acid Bacteria on Bone Structure. Authors: M. Kawakami, Ph.D., I. Ohhira, Ph.D., N. Araki, Ph.D., K. Inokihara, Ph.D., H. Iwasaki, Ph.D., and T. Matsubara, Ph.D. Research conducted at Kurashiki University of Science and the Arts, Kurashiki, Japan, Research Institution of Okayama Life Science, Okayama, Japan and Sanyo Gakuen University, Okayama, Japan. (1998)
Purification of Anti-Escherichia coli 0-157 Components Produced by Enterococcus faecalis TH10, an Isolate From Malaysian Fermented Food--Tempeh. Authors: I. Ohhira, Ph.D., H. Kurokawa, Ph.D., H. Nakaue, Ph.D., K. Inagaki, Ph.D. and H. Tanaka, Ph.D. Department of Biological Resources Chemistry, Faculty of Agriculture, Okayama University, Okayama, Japan. Published in the Milk Science Journal, Volume 49, No. 2, (2000)
Antimicrobial Effect of OM-X Against Clostridium dificile. Research study conducted at Research Center, NCIMB Japan Company, Ltd. by Research & Development, Biobank Co., Ltd. (2005)
AWARDS AND C.V. In 1991, the Japanese Dairy Science Association recognized Dr. Ohhira for his research study published in the Japanese Journal of Dairy and Food Science on the E. faecalis TH10 strain of LAB. Dr. Ohhira is acclaimed as the developer of the E. faecalis TH10 strain of bacteria. He is a recipient of the prestigious Gusi Award (2004).
Dr. Ohhira, a distinguished professor and research scientist who has lectured at universities in Malaysia, Korea and Japan, is the author or coauthor of more than 20 scientific studies on lactic acid bacteria. He has conducted research studies at Kagawa Medical College in Japan and is a respected member of important Japanese scientific societies and associations. He is a distinguished member of the New York Academy of Science and serves as the technical advisor on agricultural and environmental issues to the government of Chengda, Suchuan, China.