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Brand: MHP     Categories: Caffeine / Energy / Weight Loss


 

Dren

 

Advanced Pharmacological Approach To Fat Annihilation!

Dren uses an advanced pharmacological approach to trigger the process of lipolysis for maximum fat burning. Dren (patent pending compound name Drenbuterol) belongs to a powerful new class of compounds called mesolimbic Beta Agonist Fat Burning Agents. Its mechanism of action is similar to that of the popular old ECA (ephedra, caffeine, and aspirin) stack. Plus in addition to extreme thermogenic effects, Dren also has powerful psycho-active euphoric effects.

Item#

Brand

Name

Size

Form

Retail

Price

 

9549

MHP

Dren

30

Capsule

$39.99

$20.98

 

 



Dren

Dren  30  Capsule


Supplement Facts

Serving Size: 1 Capsule

Amount per
serving
% Daily*
Value

Drenbuterol

409

mg

**

Mesolimbic Beta Agonist Complex:

[Caffeine, L-5 Hydroxytryptophan, Beta Methoxyphenylethylamine, Yohimbine HCL]

 

 

 

**Daily value not established.


Other Ingredients:
Yellow Opaque Gelatin Capsule, Maltodextrin, Silicon Dioxide, And Magnesium Stearate.


Suggested Adult Use: Take 1 Capsule daily. Do not consume more than 1 capsule within a 12 hour period. Do not exceed recommended dose.


Warnings:
Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake. Not intended for use by persons under age 18.


Consult your physician prior to use if you are pregnant or nursing, or if you are taking medication, including but not limited to, MAO Inhibitors, antidepressants, aspirin, non-steroidal anti-inflammatory drugs or products containing ephedrine, pseudoephedrine, synephrine, phenylephrine, caffeine or other stimulants. Contains caffeine. Do not consume caffeine from other sources, including but not limited to coffee, tea, soda and other dietary supplements or medications containing caffeine.


Consult your physician prior to use if you have a medical condition, including, but not limited to, heart, kidney, liver or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache or shortness of breath.


Do not use for more than 8 weeks.

 

Step 1: Sympathometic Thermogenic Activation:

Beta-Methoxy Phenylethlyamine (also called Beta-Methoxy PEA) is an exciting new ingredient used exclusively in Dren. Beta-Methox-PEA works in part by increasing noradrenaline (NA) release from sympathetic nerve terminals. As a sympathomimetic, Beta-Methoxy PEA acts to stimulate the sympathetic nervous system. It does this by causing pre-synaptic nerve terminals to release norepinephrine, or what is commonly called noradrenaline (NA), into the synaptic space. It also has the effect of increasing circulating adrenaline, the body’s chief beta-2 agonist. Noradrenaline, once released into the synaptic space, interacts with adrenergic receptors on the surface of adipocytes (fat). This initiates a sequence of events within the adipocyte that increases lipolysis (the breaking down of fatty acids) by the enzyme hormone sensitive lipase (HSL). This fat burning effect is dependent on long and steady activation of the receptor by the agonist and is what makes the discovery of Beta-Methoxy PEA so critical and why it is much more effective than other Beta-PEA Formulas.


Beta-Methoxy PEA is the most effective B-PEA beta-agonist by virtue of its long half-life (stays in the body longer) as well as its affinity to be absorbed in fat tissue and better permeate the blood/brain barrier. In contrast, the half-life of many other Beta-PEA forms is only minutes as the enzyme MAO-B quickly metabolizes them and are less lipophilic which prevents significant concentrations from reaching the brain--- therefore no psychoactive and weight loss effect is achieved. As mentioned earlier, while the inclusion of MAO-inhibitors would seem to work the evidence shows otherwise. Beta-Methoxy PEA does not have to worry about being broken down by MAO-B due to its unique configuration. The beta “Methoxy” moiety on this compound protects it and allows for increased absorption across the blood brain barrier and deep penetration into the fatty tissues of the brain where it interacts with the aDrenergic receptors. This increase in noradrenaline and adrenergic receptors activation increases cAMP levels in fat cells (increasing its breakdown) and muscle cells (increasing protein synthesis). Beta-Methoxy-PEA’s unique configuration or moiety is what gives it its long duration of action, its exceptional ability to permeate fat tissue and extremely powerful fat burning effects. I can’t emphasize the point enough: it’s the “Methoxy” in Beta-Methoxy-PEA that makes it simply unmatched to all other forms of Beta PEA no matter what jargon you read--and its only found in Dren!


In addition, Beta-Methoxy Phenethylamine’s enhanced moiety and ability to better penetrate the blood brain barrier elicits extreme euphoric “feel good’ neuro-sensory. Beta-Methoxy-PEA, is an alkaloid and monoamine, therefore, it is believed to function as a neuromodulator or neurotransmitter and elicits extreme psychoactive effects on the body while burning body fat at an unforseen rate. To sum it up, Beta-Methoxy Phenethylamine freely enters the brain barrier and triggers a cascading release of norepinephrine, dopamine and serotonin and stimulates the mesolimbic reward pathway, causing euphoria and excitement.


Step 2: The Inclusion of an Alpha 2 Agonist works to further Enhance Beta-Methoxy PEA fat burning!

While Beta-Methoxy-PEA by itself is a remarkably effective thermogenic, the scientists at MHP wanted to take fat burning to a new level. Let’s face it ever since the FDA banned ephedra everyone has been looking for an alternative. MHP wasn’t only looking to develop an ephedra alternative we were looking to take it way beyond the ECA stack. Once we isolated Beta-Methoxy-PEA and saw its similar yet superior mechanisms of actions as ephedra we knew we could do it.


In response to Beta-Methoxy-PEA’s beta-adrenergic stimulation, negative feedback mechanisms are activated as well. This negative feedback can shutdown lipolysis (fat burning). The alpha 2 receptor, phosphodiesterases and adenosine try to slow down or halt the fat burning process. In the case of Dren, Beta-Methoxy-PEA undergoes these negative feedback mechanisms. Therefore, measures had to be taken to maximize Beta-Methoxy-PEA’s actions in the body and minimize these negative feedback mechanisms.


All forms of Beta-PEA are considered non-selective adrenergics through the release of noradrenaline because they don’t just active one type of receptor. Unfortunately, noradrenaline functions as its own negative feedback signal by activating both the beta and alpha adrenergic receptors. As you recall, the stimulation of beta receptors is good as it initiates the fat burning process, but the Alpha 2 receptors actually shut down lipolysis (fat burning). MHP scientists added Yohimbine HCL to the Dren formula to bypass Alpha 2 receptor binding and increases the effectiveness of Dren. Yohimbine HCL is a selective alpha 2 antagonist and can thus short circuit this feedback loop, maximizing noradrenaline levels and the overall fat loss actions of Beta-Methoxy PEA. What we have created is a mechanism of action which is long acting activation on the beta receptor with little to no activity at the alpha receptor. Resulting in the most powerful thermogenic activity in adipose tissue possible.


Step 3: Phosphodiesterase Inhibitibiton and Adenosine Receptor Interferance

Most people like caffeine because of its stimulatory and energizing effects. But, caffeine has a much more important role than that in Dren. Stimulation of Beta-adrenergic receptor also means an increase in phosphodiesterase and adenosine activity. Phosphodiesterase (PDE) acts to hydrolyze cAMP into inactive fragments while adenosine inhibits cAMP accumulation halting the stimulation of HSL and the fat burning process. Caffeine possesses the ability to inhibit phosphodiesterases within the cell and has even been shown to have the ability to prevent some re-uptake of norepinephrine while also acting as an adenosine receptor blocker. As you can see, caffeine provides important powerful synergies to maximize Dren’s fat burning effects.


Step 4: Powerful Psycho-active “Feel Good” Neurostimulation

The mind is a powerful thing! Dren will not only transforms your body with the most powerful fat burning thermogenic experience, it will also alter you mind and put you is a place you want to be: “On Top of The World”. There is no denying it Beta-Methoxy-PEA is very psycho-active and triggers a euphoric “feel good response”. To further enhance Dren neuromodulator activity L-5-Hydroxytryptophan has also been added to the formula. L-5-Hydroxytryptophan is a naturally-occurring amino acid, a precursor to the neurotransmitter serotonin which is a monoamine neurotransmitter with feel good and appetite suppression properties. L-5-Hydroxtryptophan like Beta-Methoxy-PEA also passes through the blood brain barrier into the brain. It’s psychoactive action are thought to be derived from its effect on serotonin synthesis in central nervous system tissue. It is believed that a high supply of L-5-Hydroxytryptophan causes the brain's serotonin-producing neurons to increase production leading to increased serotonin release. The serotoninergic system is known to help modulate mood, emotion, sleep and appetite and thus is implicated in the control of numerous behavioral and physiological functions. L-5-Hydroxytryptophan helps to keep serotonin and norepinephrine levels in balance therefore increasing metabolism and fat loss through synergistic actions with other ingredients in Dren. The end result is an extreme “feel good” state of euphoria.


The fact is, Dren (Drenbuterol) belongs to a powerful new class of compounds called mesolimbic beta agonist, which have extremely powerful fat burning and euphoric activity and should be taken with caution. Dren stimulates both metabolic and mesolimbic pathways for extreme thermogenic fat burning and neurotropic “feel good” sensory. Each Dren capsule provides the maximum 470mg dose of Drenbuterol and should only be administered once daily and should not be used with other stimulants. When take as directed, Dren will help potentiate thermogenic fat burning, increase energy levels, suppress appetite and illicit a state of heightened mental euphoria.

 

 


 






 
 

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Products on this site are not intended to diagnose, treat, cure, or prevent any disease. 
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The majority of the product information has been reprinted from the manufacturer.