For nearly 2800 years, the Chinese have used extracts from the Ginkgo biloba tree to treat a variety of conditions. Ginkgo helps promote healthy brain, metabolic, and cardiovascular function (i.e., blood, blood vessels, circulation).150-170 Ginkgo contains numerous antioxidants such as proanthocyanidins and flavonoids that counteract free radical activity. Flavonoids are also known to strengthen capillaries, which can promote healthy blood flow to the brain to help maintain cognitive health.153,158,167
The premium-quality botanical extract in Ginkgo Biloba Certified Extract™ has been concentrated and dual-standardized to ensure the highest quality, consistency, and biological activity.
• Help maintain normal circulation by dilating blood vessels and reducing the stickiness of blood platelets160,161
• Help maintain the normal function and tone of blood vessels,153 and maintain a normal blood flow150,152,159
• Maintain already normal oxygen and glucose metabolism in the brain154-157
• Maintain normal coagulation of blood161,162
• Reduce tissue damage caused by low blood flow154,161
• Help control radiation-induced brain edemax in vitro163-164
• Help slow the aging process in the brain159,165-168
Ginkgo biloba extract is reputed as a neuroprotective antioxidant agent.169 It is known to protect the energy-producing mitochondria within the cells, thus enhancing oxygen utilization and cellular respiration.
In a study to determine whether ginkgo extract could prevent age-associated cellular changes, the brain and liver mitochondria of old mice fed ginkgo extract in their drinking water was compared to those of young and old control mice. Mitochondria from the rats given ginkgo exhibited significantly less genetic damage, peroxide generation, and oxidation of the crucial antioxidant glutathione than non-supplemented rats. In addition, mitochondria from old rats given the ginkgo extract resembled those of young rats much more closely, being similar in size and morphology. The study concluded that standardized ginkgo extract prevents age-related decline in mitochondrial structure and function by protecting mitochondria from oxidative damage.170
The phytonutrient profile of Ginkgo Biloba Certified Extract™ is comparable to the GBE 24/6 extract used in clinical studies worldwide and monographed in German Commission E. The health regulatory agency that regulates ginkgo purity in Germany mandates that ginkgo not contain more than 5 ppm of ginkgolic acid. Ginkgo Biloba Certified Extract™ contains less than 1 ppm of ginkgolic acid. Ginkgolic acid is a substance related to anacardic acid (poison ivy) and may cause an allergic reaction in some people. Ginkgo Biloba Certified Extract™ has the lowest ginkgolic acid level commercially available.
Ginkgo Biloba Certified Extract™ has high levels of ginkgolide B (>0.8%), which is the most studied terpene lactone and thought to be a major regulator of platelet activating factor (PAF). PAF is a powerful physiologic- responses mediator for many processes.170