GliSODin® (The Antioxidant Catalyst) 100 mg Fact SheetNeil E. Levin, CCN, DANLA 01/31/05
LIKELY USERS: People with exposure oxidizing chemicals; People wanting to increase their body’s production of antioxidants.
KEY INGREDIENT (S): SOD (Superoxide Dismutase antioxidant enzyme) from melons Organic Wheat Grass leaf
MAIN PRODUCT FEATURES: Patented, clinically tested form of SOD to ensure absorbability; Protects cell mitochondria from oxidative stress that leads to genetic damage the cells; Reduces markers of cellular oxidative damage in the blood; May increase the body’s production of important antioxidants including SOD, Glutathione and Catalase.
OTHER IMPORTANT ISSUES: This product contains wheat protein as an aid to protecting the SOD and increasing its absorption. The base of organic wheat grass synergistically provides additional, naturally occurring levels of SOD and other nutrients, though this additional SOD is not well absorbed.
AMOUNT and HOW TO USE: One to three capsules a day, preferably between meals.
COMPLEMENTARY PRODUCTS: Alpha Lipoic Acid, EGCg Green Tea Extract, Whey Protein Isolate, Selenium, NAC, Vitamin C, other Antioxidants.
CAUTIONS: Contains wheat and wheat proteins, should not be used by people who are gluten-intolerant. Gluten intolerance may manifest with neurological, not abdominal symptoms, so please consider having a gluten intolerance test if you do have any neurological problems. Please notify your physician about your supplement use if you are using any drugs! Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
REFERENCE:
Free Radic Res. 2004 Sep;38(9):927-32. Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Muth CM, Glenz Y, Klaus M, Radermacher P, Speit G, Leverve X. Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum Ulm, D-89073 Ulm, Germany. PMID: 15621710 [PubMed - in process]
Think Radical Self-Defense...Think GliSODin®
By Nick Rana, NOW Quality Assurance Department
The human body is a miraculous creation designed to interact with many forms of stimulus from both internal and external forces, maintaining a biological balance of health called homeostasis. We are constantly separating substances needed to sustain life and enable our immune and repair systems to operate efficiently from undesirable substances in our air, food and water.
In the course of normal, daily body functions the very elements designed to keep us alive and healthy - like oxygen - may also be involved in creating substances such as oxygen free radicals that, uncontrolled, can cause cellular destruction and disease. Physical training and exercise, desirable for muscular tone and cardiovascular health, can increase cellular oxidative stress by increasing the body’s need for cell-protecting antioxidants and causing symptoms of aging.
There are two main types of antioxidants. Exogenous forms are taken in from external sources like food and supplements. Endogenous forms are internally produced. External sources of antioxidants are foods and supplements that are rich in vitamins A, C, E, beta- carotene and a variety of compounds like bioflavonoids and polyphenols.
Thankfully, our Creator designed our bodies to manufacture certain intracellular antioxidant enzymes like Super Oxide Dismutase (SOD), Catalase (Cat) and Glutathione peroxidase (GPx). The SOD enzyme system exists in three different forms based on different minerals. These antioxidant enzymes play an important intra-cellular protective role by inactivating one of the most destructive enemies of human cellular health, the super-oxide anion free radical. Zinc, copper and manganese are the minerals that aid in forming the three members of the SOD enzyme family.
SOD compounds are found naturally in broccoli, Brussels sprouts, cabbage, melon and most green foods like barley grass. The problem is that SOD does not survive the different chemical and pH challenges our digestive tracts subject it to. Also, as we age our bodies produce less SOD and we inevitably suffer the effects of free radical damage leading to aging. We begin to experience inflammatory conditions and compromised immune systems, further increasing our need for this powerful antioxidant.
In order to provide the highest quality SOD available, we looked for a manufacturer who had performed both laboratory chemical analyses and human clinical trials to ensure the bioavailability and stability of this important cellular protector. What we found was a naturally occurring SOD enzyme derived from cantaloupe (Cucumis melo) that has been complexed with a wheat protein called gliadin. This material is called GliSODin®. The natural wheat-derived protein coats and protects this vulnerable material from stomach acids and digestive enzymes that could otherwise destroy its structure and antioxidant potential.
Laboratory stability studies performed by ISOCELL Nutra SA have proven that this natural GliSODin® matrix is very shelf-stable. The real test of stability and efficacy is how well SOD travels from the human gut into the bloodstream. Whole blood analyses must confirm that it actually gets to the absorption site in the small intestine virtually intact and is properly absorbed to produce measurable increases in SOD antioxidant levels in the blood providing DNA protection at the cellular level.
A double blind, randomized and placebo-controlled human study was conducted on twenty volunteers who were exposed to 100% hyperbaric oxygen to evaluate the extent of DNA damage caused by oxidation. The levels of cellular DNA damage were lower in the GliSODin® group and another marker of oxidative stress called isprostane was also reduced.
In another human study, healthy volunteers supplemented their diets with 1,500 mcg. of GliSODin® for four weeks. Prior to GliSODin® use, the volunteers participated in strenuous exercise and baseline measurements of serum total antioxidant status, plasma lactate accumulation and several other markers were taken. After supplementation, the exercise was repeated and the oxidative stress markers were measured once again. GliSODin® supplementation resulted in a significant change in oxidative status and a significant decrease in exercise-induced lactate (lactic acid) release, suggesting that damage caused by oxidative stress was significantly inhibited. Lactic acid produced by exercise is a cause of muscle pain and fatigue during exercise.
GliSODin® has been shown to increase levels of all three principal antioxidant enzymes - SOD, Glutathione Peroxidase and Catalase – in multiple animal studies and in humans with depressed SOD levels due to compromised immunity or environmental stress factors. This is an unforeseen benefit of taking GliSODin®.
The successful results, documented by published human studies, were evidence enough for the NOW Foods New Product Development Team to decide to market GliSODin®, and we expect it will be one of the most powerful weapons that we’ve developed ‘to empower our customers to live healthier lives’. Our team looks at evidence produced by well-designed scientific research to help us to produce quality natural products.
Reference:
Y. Kong, et al., Korea Cancer Center Hospital, “Influence of an orally effective superoxide dismutase (GLISODin)® on strenuous exercise-induced changes of blood antioxidant enzymes and plasma lactate” AACC Poster, Presented July 2004 Muth CM, Glenz Y, Klaus M, Radermacher P, Speit G, Leverve X. Free Radic Res. 2004 Sep;38(9):927-32. Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum Ulm, D-89073 Ulm, Germany. PMID: 15621710 [PubMed - in process] (“Free Radical Research” journal) |
