Outrageous
and True…
We've Made Ephedra Obsolete!
by Tim Patterson
with Bill Roberts and Cy Willson
Bottom
line, we've made ephedra and the current crop of fat-loss supplements obsolete!
This is definitely not an
overstatement.
What makes our invention
so valuable and unique? First of all, it's far more effective at burning off
body fat than anything that's ever been on the market. Furthermore, unlike ephedra-based
formulas, it doesn't down-regulate beta-receptor sites and become ineffective
over time.
And get this… It also
increases protein synthesis and the natural production of anabolic substrates
(in both men and women). In other words, it may actually help to preserve or
even build muscle mass.
Even better yet, all of
these metabolic benefits are sustained, around the clock, week after week, as
long as you continue to take the formula.
We honestly believe that
we've developed the fat-loss phenomenon that everyone's been hoping for. Ever
since the ripped look's become the passionate desire of every body-conscious
individual, there's been a quest for a fat burner that, in addition to continuously
melting off adipose tissue, would help to preserve -- even promote -- muscle-mass
gains.
And we've done it! Not only
that, it's far more effective than any of us involved with the project ever
dreamed possible.
The name of our fat-loss
phenomenon is HOT-ROX, and there's no doubt in our minds that, after reading
what follows, you'll be a believer, too.
What's the Big Deal with Ephedra, Anyway?
Why is everyone
so focused on adrenergic compounds, like ephedra? A better thermogenic mousetrap
should've replaced them years ago. Unfortunately, instead of being innovative,
supplement companies became complacent, relying heavily upon the jitter-buzz
factor (not the popular dance of the 1920s, but the feeling you get from ephedra)
to sell their products.
Think about it… If
ephedra-based products were all that effective, why are you reading this article?
How many bottles of fat-loss supplements have you purchased in the last five
years, anyway? If you're like most of us, you've spent a small fortune and you're
still not as lean as you want to be.
I don't know why this isn't
obvious to everyone, but adrenergic compounds, in and of themselves, aren't
all that powerful. In fact, ephedrine, in the absence of caffeine, is barely
even worth considering as a fat-loss agent. Furthermore, if you attempt to keep
ephedrine levels continuously elevated (24/7), which is what's required for
optimal fat loss, beta receptors eventually down-regulate, making ephedra even
less effective.
Rapid Fat Loss -- A Mission of 2 Tasks
The first
thing to understand about fat loss is that almost everyone has the science backward.
They hope that by burning energy, say on a Stairmaster, it will somehow suck
the fat right out of their blurred abs or other problem areas. This simply isn't
true. There is no pipeline through which muscle can pull fat from adipocytes.
There must be ample supplies of fatty acids in the bloodstream to use as fuel
or the muscle burns itself!
People also hope that cutting
calories will guarantee fat loss. This also isn't true. Again, energy-burning
or energy deficits won't suck fat from the fat cells. The energy can and often
will come from glycogen or muscle protein. And most important, caloric reduction
slows the metabolism and can actually interfere with fat release!
Once this occurs, you're
in a physiological nightmare… a state that not only makes it nearly impossible
to lose any additional body fat, but you also begin to lose muscle mass as well,
leaving you skinny-fat.
Triggering lipolysis is
the crucial first step, but you must also support the burn. If not, it's perfectly
plausible to stimulate lipolysis only to have the fat redistributed back into
adipocytes. What a waste of time!
If your goal is to get as
lean as possible while maintaining or even gaining muscle mass, in addition
to managing caloric intake, you must successfully accomplish two and only two
critical tasks. Everything else is subordinate to these:
1) Support rapid lipolysis
(fat release) while simultaneously minimizing lipogenesis (fat creation).
2) Keep the TCA* cycle primed
for maximum, aerobic-metabolic burn.
*Note: The TCA (tricarboxylic
acid) cycle is also known as the Krebs cycle or aerobic metabolism.
TASK 1 -- Release the Fat Hounds!
Lipolysis
Up, Lipogenesis Down
Simply put, the goal here
is to get fat cells to release fat (lipolysis) faster than they create fat from
dietary calories (lipogenesis).
If you want to induce lipolysis,
you have to increase cAMP (cyclic adenosine monophosphate). Cyclic AMP is responsible
for triggering the cellular processes for lipid metabolism. In other words,
it's the chief gatekeeper for stimulating lipolysis and slowing lipogenesis.
Ramping up cAMP within fat
cells activates protein kinase, which in turn activates hormone-sensitive lipase,
the enzyme that breaks down the fat in adipocytes. This causes fatty acids and
glycerol to be released into the bloodstream.
High sensitivity to hormone-sensitive
lipase depends upon ample thyroid hormone being present. If T3 levels are low,
lipase activity won't increase as it should. In contrast, increased cAMP in
combination with high T3 levels will send lipolysis rates through the roof.
Cyclic AMP can be stimulated
directly by increasing adenylate-cyclase activity. Adrenergic compounds (endogenous
or exogenous) can also indirectly increase cAMP by activating adenylate cyclase
when binding beta receptors. The adrenoreceptor route, as mentioned before,
has its limitations.
Additionally, both increased
cAMP and high T3 levels decrease lipoprotein lipase activity, which is an enzyme
responsible for lipogenesis. So in addition to stimulating lipolysis, cAMP and
T3, as a team, put the kibosh on lipogenesis as well.
This double-whammy effect
that cAMP and T3 deliver is very powerful, priming the body for the burn.
TASK 2 -- Prime the TCA Cycle
Ignition
and Burn
When lipolysis outraces
lipogenesis and releases fatty acids into the blood, they diffuse into all cells
of the body to be used as fuel.
Upon entering a cell, fatty
acids are actively transported, via carnitine acyltransferase, into mitochondria,
which act as cellular power plants. Once in the mitochondria, the fatty acid
is converted into fatty acid-CoA. Next, the fatty acid-CoA is broken down further,
two carbons at a time, into acetyl-CoA. This is the "fat" that fuels
aerobic metabolism through the TCA (tricarboxylic acid) cycle. In other words,
when you think of burning off body fat, the "fat" being consumed is
actually acetyl-CoA.
This is when T3 plays another
huge role. T3 produces thermogenic malic enzyme, which is the intermediary required
to produce oxaloacetate. And oxaloacetate, in combination with acetyl-CoA, fuels
the TCA cycle. For maximum thermogenesis, via the TCA cycle, oxaloacetate needs
to be present in ample amounts or the entire process falls apart.
This is a weak link in the
TCA cycle and requires exogenous support through nutritional means if you want
to maintain continuous and rapid fat loss. (Just how you do that through nutritional
means is something I'll go over later.)
Additionally, T3 increases
UCP3 uncoupling protein, which can have profound effects on fat loss. In fat
cells, uncoupling dramatically increases lipolysis. And in other tissues, like
in muscle, uncoupling increases metabolic rate, thus supporting the burn. The
net effect is faster fat release from adipocytes, followed by faster fat burning
due to an overall-increased metabolic rate.
The Whole Fat-Loss Enchilada
Bottom
line, if you ramp up and sustain high cAMP and T3 levels, you've done all that's
required for maximum, continual fat metabolism. In essence, you've achieved
what's tantamount to thermogenic nuclear war.
(Managing food intake is,
of course, also required; hopefully that's obvious.)
So how do we formulate a
supplement that sustains non-beta-receptor-mediated cAMP and increased T3 levels
without causing down-regulation?
Well, we have the answer.
Specifically, we've developed a series of compounds that when combined, produces
a more profound effect than our greatest expectations. In fact, at this point,
we can't imagine anything better.
The horsepower that fuels
HOT-ROX is comprised of two novel compounds and their synergists. The big daddy,
which is also the real magic behind our formula, is called A7-E™. A7-E
was designed from scratch by Bill Roberts and is best described as a tricked
out, supercharged version of 7-keto DHEA.
A7-E is completely new to
the industry; it has a patent filed on it; and it's so powerful on its own as
a fat-loss agent that there's no contest when compared to anything else that's
currently on the market. A7-E launches us right smack dab in the middle of a
new fat-loss era!
A7-E™ -- Rev Up and Potentiate Thyroid Activities
The most challenging
task was finding a way to boost T3 levels without suppressing TSH. From the
scientific literature, there are two compounds that when taken together in relatively
high dosages, would do the trick nicely: 7-keto DHEA supported by guggulsterones.
7-Keto DHEA has been shown
to increase T3 in humans by as much as 30% (200 mg/day) without suppressing
TSH! Additionally, and to a much greater degree, 7-keto DHEA increases thermogenic
malic enzyme. Remember, malic enzyme is the compound responsible for producing
oxaloacetate, which fuels the TCA cycle.
Guggulsterones, on the other
hand, increase the peripheral conversion of T4 into T3, making it the ideal
complement to 7-keto DHEA. Increasing the peripheral conversion of T3 is very
important because the thyroid only produces 20% of the body's T3. Most of the
remaining 80% is derived from T4 through a conversion process that occurs in
various target tissues, like skeletal muscle, for example.
On the surface, 7-keto DHEA
and guggulsterones appear to be great choices for the HOT-ROX formula. Unfortunately,
however, both have inherent problems which needed fixing if we were to achieve
the desired magnitude of effect. In other words, we wanted to improve the wow
factor by a bunch.
In essence, the bioavailability
of 7-keto DHEA isn't high enough and its active life is far too short. Furthermore,
of the entire family of androst-5-ene compounds researched, 7-keto DHEA didn't
show the best performance when converting into the active species androst-5-ene-3,7,17-triol
(A5-T). And since A5-T is the compound that elicits profound thermogenic actions,
why not use the androst-5-ene derivative that shows the greatest conversion
rate?
The superior choice is androst-5-ene-7-one-3,17-diol
(A7-D), which has 3x better conversion into the active A5-T. So A7-D is our
top choice for the job. And to improve both bioavailability and length of active
life, Bill engineered A7-D into a carbonate ester, called androst-5-ene-7-one-3,17-diethylcarbonate,
or A7-E.
A7-E, due to its superior
rate of conversion into A5-T, its longer active life, and its increased bioavailability,
represents a quantum leap beyond 7-keto DHEA, making it a real powerhouse for
fat loss.
With its enhanced molecular
design, A7-E is the premier fat-loss compound of our time. In and of itself,
it's a very powerful and effective fat-loss agent. But we didn't stop there…
We wanted a synergist for
A7-E. All of our research pointed to one obvious candidate -- guggulsterone
-- because it increases the peripheral conversion of T4 into T3, further supporting
the actions of A7-E. The problem, however, is guggulsterones are not available
in a pure state. They're found in a plant called Commiphora mukul, which contains
only small amounts of guggulsterone Z and E.
Unfortunately, a good Commiphora
mukul extract is only 2.5% active, and that alone makes using an herbal extract
unfeasible. Additionally, it's very difficult to get consistent raw material,
making accurate dosing literally impossible. And if these weren't big enough
problems, there are other constituents in the plant material that cause rather
severe allergic reactions in a significant portion of the population.
Our only solution was to
produce 100% pure guggulsterones, preferably with a 2:1 ratio between Z and
E. And that's just what we did. We included two parts purified guggulsterone
Z to one part purified guggulsterone E in our HOT-ROX formula.
So to recap, A7-E has the
incredible ability to stimulate the production of T3 and thermogenic malic enzyme;
and pure guggulsterones further enhance (synergize) these activities by facilitating
the peripheral conversion of T4 into T3.
SCLAREMAX™ -- The King of Cyclic AMP
The second novel
compound in HOT-ROX is called Sclaremax. Sclaremax is a diterpenoidal lactone
found in a plant called Salvia sclarea. It's known to be an extremely potent
adenylate cyclase activator, very similar to that of the diterpene derivative,
forskolin. In fact, cyclic AMP assays indicate Sclaremax either equals or exceeds
the actions of forskolin, but with a much longer active life.
Additionally, like forskolin,
Sclaremax stimulates adenylate cyclase independently of beta-2 receptors, which
means it has no limitations because it won't down-regulate and it has a higher
maximal effect. In other words, the more you take, the greater the effect --
day after day after day…
So Sclaremax essentially
mimics or acts like TSH -- activating adenylate cyclase in the membrane of thyroid
cells, which in turn elevates cyclic AMP and eventually leads to thyroid hormones
being released. It may also enhance the cyclic AMP response to TSH in thyroid
cells as well.
And because Sclaremax produces
an accumulation of cyclic AMP, it will also increase nitrogen retention. This
means that it will help preserve or even build lean-body mass (muscle) while
increasing lipolysis.
Another huge bonus in comparison
to ephedra and other beta agonists is that Sclaremax doesn't interact with beta-1
adrenoreceptors and over stimulate cardiac tissue or raise blood pressure. In
fact, Sclaremax, in very high doses, exhibits a vasodilatory effect and slightly
decreases blood pressure.
Some other benefits of Sclaremax
include its antithrombotic and antidepressant effects, as well as its stimulating
effect on luteinizing hormone, via cyclic AMP, resulting in the production of
additional Testosterone (in males).
To synergize the effects
of Sclaremax, we included the methylxanthine caffeine. Caffeine is a potent
competitive inhibitor of phosphodiesterase enzyme, which is responsible for
the inactivation of cyclic AMP.
In comparison to caffeine,
Sclaremax increases the formation of cyclic AMP, whereas caffeine acts to prevent
its degradation. In other words, caffeine potentiates the effects of Sclaremax,
thus increasing the magnitude of cyclic AMP accumulation.
And since Sclaremax and
caffeine increase cyclic AMP, but via different mechanisms and not through the
beta receptor, a combination produces a powerful, synergistic effect on lipolysis.
So you can see that, even
though A7-E, Sclaremax, guggulsterones, and caffeine have discrete roles in
the fat-loss process, they also potentiate one another's activities, making
the combination extremely powerful.
Brain
Chemistry -- Elevate Mood and Suppress Appetite
We also wanted
to utilize compounds in our formula that elevate mood and suppress hunger, especially
for carbohydrates. To do this, we included ample amounts of acetyl-L-tyrosine
and 5-hydroxy-L-tryptophan to maximize brain levels of norepinephrine, dopamine,
and serotonin, all of which tend to decrease while following a calorie-restricted
diet.
Maintaining high levels
of norepinephrine, dopamine, and serotonin will not only elevate mood and suppress
appetite, but:
• Decrease fat
storage
• Stimulate oxygen
consumption
• Increase resting
energy expenditure
• Decrease insulin
levels.
HOT-ROX Isn't for Everyone.
If you're
not going to take fat loss seriously and be disciplined with your diet, please
don't buy the supplement. I don't care what you take or what you do in the way
of exercise, if you eat half a smorgasbord every day you're gonna' get fatter.
On the other hand, if you're
really committed to doing your part, incorporating sound training and dietary
guidelines, we promise that HOT-ROX will be the most effective fat-loss agent
you've ever used. It's expensive relative to other products on the market; but
when you compare its effects, HOT-ROX is more than just a bargain -- it's a
steal!
Just remember how much you've
spent on fat-burners over the years and see where that's gotten you. 'Nuff said.
In summary, HOT-ROX…
• Ramps up lipolysis,
releasing fat from adipocytes more rapidly than ephedra-based products to the
point of no contest.
• Minimizes lipogenesis
(fat creation) via increased cAMP and T3.
• Maximizes and
sustains metabolism around the clock, turning fat into heat energy, through
two powerful mechanisms:
Fueling
the TCA cycle
Stimulating
mitochondrial uncoupling
• Provides an
inexhaustible supply of the weak-link substrate oxaloacetate and thus keeps
the TCA cycle primed for sustained, maximum fat burn.
• Elevates and
maintains not only the increased production of T3, but the peripheral conversion
of T4 into T3 as well, without suppressing TSH (natural thyroid production).
• Doesn't over
stimulate cardiac tissue or raise blood pressure.
• Preserves or
even promotes muscle-mass gains.
So if you want maximum fat-burning
effects to work continually, around the clock (24/7), HOT-ROX is the perfect
supplement for you!
HOT-ROX
Fat-Loss Phenomenon
Bill Roberts, Cy Willson,
and I believe that HOT-ROX represents our best work to date. In summary, it's
the first and only designer fat-loss formulation ever to produce a rate and
magnitude of fat loss that makes being ripped attainable and maintainable for
most individuals.
With just A7-E alone, we've
effectively made all ephedra-based products and their weaker siblings obsolete.
And when combining Sclaremax and all of the synergists with A7-E, there's a
potentiation effect that will blow you away. In addition to melting off fat
like never before, you'll notice that you feel either curiously warm or downright
hot!
So if you want to wage thermogenic
war against all those pesky adipocytes -- thus allowing you to attain and maintain
the level of leanness that you've been struggling so long to achieve -- HOT-ROX
is the only supplement that provides these nuclear weapons.
Bottom line, HOT-ROX is
the most powerful and most-effective sports supplement ever developed for fat
loss, period. Outrageous and emphatic statement? You betcha, and it's true!
HOT-ROX is truly a fat-loss
phenomenon!
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