Helps Maintain Healthy, Smooth Joint Function* The effect of Hyal-Joint™ on joint function and comfort in humans was recently studied in a pilot clinical trial. The study subjects were men and women at least 40 years old who experienced noticeable deterioration of joint comfort on a regular basis.The participants were randomly assigned to take either 80 mg of Hyal-Joint™ or a look-alike placebo capsule every day for eight weeks. Each participant’s joint health and function status was evaluated at the beginning of the trial, and again after four and eight weeks. Assessment was done using the WOMAC Index, a self-administered questionnaire that measures 24 parameters of joint function, and a 36-question survey of physical and mental health and well-being. Statistical analysis of the data showed Hyal-Joint™ to be efficacious for improving physical function, joint comfort and quality of life.1
Nourishes Joint Fluid for Free and Easy Movement*
As described earlier, hyaluronic acid is necessary for the synovial fluid to perform its lubricating function in joints. Studies on the intra-articular injection of hyaluronic acid into joints suggest that exogenous HA potentiates endogenous production in synovial fibroblasts (synoviocytes). 2 In a cell culture (in vitro) study, Hyal-Joint™ effectively stimulated endogenous synthesis of hyaluronic acid in synoviocytes.3
It has been observed that a diminished content of hyaluronic acid in joints––with a concomitant loss of its elastic, lubricating benefits–– occurs in tandem with sub-optimal joint health and function.4 As joint health declines, the amount of hyaluronic acid in synovial fluid (intra-articular content) is reduced.5 Hyal-Joint™ was studied for its ability to increase the hyaluronic acid concentration in joints of horses with poorly functioning joints. In a small pilot trial, oral administration of Hyal-Joint™ for 60 days measurably increased both the quantity and quality of hyaluronic acid of the tarsocrural joint (the articulation between the tarsal bone of the foot and the tibia and fibula), while at the same time improving walking ability.6
Scientific References
1.Kalman DS, Heimer M,Valdeon A, et al. Effect of a natural extract of chicken combs on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal 2008; 7:3.
2.Ghosh P, Guidoli D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent? Semin Arthritis Rheum 2002;32(1):10-37.
3.Unpublished study conducted at the Rheumatology Service Research Unit; Hopsital Juan Canalejo, L Coruña, Spain.
4.Miltner O, Schneider U, Siebert CH, et al. Efficacy of intraarticular hyaluronic acid in patients with osteoarthritis-a prospectic clinical trial. Osteoarthritis Cartilage 2002;10(9):680-6.
5.Brockmeier SF, Shaffer BS. Viscosupplementation therapy for osteoarthritis. Sports Med Arthrosc Rev 2006; 14(3):155-62.
6.Martínez-Puig D, Carmona JU, Argüelles D, et al. Oral hyaluronic acid (Hyal-Joint™) administration improves OCD clinical symptoms and slightly increases intra-articular concentration of hyaluronic acid in a horse model: a pilot survey. Presented at the World Congress on Osteoarthritis. Dec 6-9, 2007; Ft. Lauderdale, FL.
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