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Omega-6 fatty acids are well-supplied in the diet by meat and vegetable oils. However, not all omega-6 fatty acids are of equal value. Linoleic acid (not to be confused with ALA, which is in the omega-3 family) and arachidonic acid (AA) tend to be unhealthy because they are the precursor of inflammatory eicosanoids, such as prostaglandin E2 (PGE2), thromboxane A2, and leukotriene B4, which promote inflammation. In contrast, gamma linolenic acid (GLA), found in evening primrose oil, borage oil, and black currant oil, is an important fatty acid that plays a beneficial role in healthy prostaglandin formation.59 Health conscious people have been consuming a lot of borage oil to obtain GLA, the parent of the biologically active DGLA (di-homo-gamma-linolenic acid).
Life Extensionís Mega GLA provides 285 mg of GLA plus 10 milligrams of sesame lignans. These sesame lignans increase beneficial DGLA, and they also help reduce the production of proinflammatory arachidonic acid, which is responsible for the formation of destructive prostaglandin E2 and leukotriene B4.60 Numerous studies have documented GLAs multiple health effects, but information about the ability of sesame to prevent the conversion of GLA into arachidonic acid indicates that many more people may now be able to benefit from supplementing with GLA.61
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