Item# Name Size & Form Brand Price Actions
Item# 3052930529 Optimized Folate 1,000mcg
by Life ExtensionLife Extension $21.00 Wishlist
Optimized Folate 1,000mcg

Supplement Facts

Serving Size: 1 Vegetarian Capsule

Amount per
% Daily*

Folate [as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt]^




*Percent Daily Values are based on the 2000 Calorie Diet. Your daily values may be higher or lower depending on your calorie needs.

Other Ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.

Contains no: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Take one capsule daily with food, or as recommended by a healthcare practitioner.

^Quatrefolic® is a registered trademark of Gnosis S.p.A.

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Optimal levels of folate are necessary for healthy cell division and protein synthesis and are especially important for the maintenance of a healthy GI tract. The systemic need for folate increases in certain states in which increased cell multiplication is needed. Chronic use of medications such as aspirin in therapeutic doses and antacids can interfere with the metabolism of folate.178

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).180 Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status181 compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency182 since it requires no conversion to become metabolically active.

A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.183

People with elevated homocysteine levels have a greater risk of cognitive decline.184 Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12),185 vitamin B6, and riboflavin.186,187


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Prices are subject to change at anytime and without notice. The majority of the product information has been reprinted from the manufacturer.