Alpha-amylase is a digestive enzyme that breaks down starch into smaller carbohydrate units that can subsequently be broken down into the simple sugar, glucose. Glucose is absorbed directly into the bloodstream following its uptake by intestinal cells, resulting in a relatively rapid rise in serum glucose levels. Glucose is used by all cells of the body to fuel metabolism. Excess glucose, however, can be converted into fat and stored in adipose tissue.*
What is Phase 2™ Starch Neutralizer?
Phase 2™ is an amazing, non-stimulant, all-natural nutritional ingredient that is derived from the white kidney bean. It is the first nutritional ingredient that has been clinically & scientifically proven to neutralize starch, found in your favorite foods such as potatoes, breads, pasta. rice, corn and crackers.
Phase 2™ is a safe yet powerful nutritional ingredient, clinically studied to reduce the absorption of starch calories.
Phase 2™ allows you to enjoy those foods that you love without all the calories.
How does Phase 2™ work?
During the digestive process, your body converts carbohydrates, found in starchy foods such as potatoes and pasta, into sugar. Your body does this by breaking-down the carbohydrate molecule with alpha amylase, an enzyme that is produced in the pancreas.
These sugar calories are either burned off, through exercise, or stored as fat cells for future use. Unfortunately, inactivity means that these stored fat cells accumulate. The result is weight gain.
When should I take Phase 2™?
Recent research has shown the most optimum time to take Phase 2™ is just before a starch-rich meal along with 8 oz of water. However, the studies also showed that Phase 2™ could still provide some of its starch "neutralizing" benefits when taken during, or just after, a starch-rich meal. One such study demonstrated that Phase 2™ could remain effective when a capsule is opened and sprinkled onto food.
Does Phase 2™ cause any toxic side effects?
A dose equivalent to 74 grams taken daily for 90 days by a 165 lb. person showed no signs of toxicity. Pharmachem Laboratories Inc., announced that a Chronic Toxicity Study (L.D.50) demonstrated that Phase 2™ Starch Neutralizer™, the first standardized white bean extract used in a variety of weight loss supplements, is safe and non-toxic.
“Phase 2™ showed no signs of chronic toxicity at doses up to 1.0 gm/kg body weight for up to 90 days,” said Ramadasan Kuttan, Ph.D., director, Amala Cancer Research Center, Thrissur, India, who conducted the study along with R. C. Srimal, M.D. “The data indicates that administration of Phase 2™ for 90 days did not produce any adverse reaction as seen from the organ weight, necropsy, haematological values and biochemical values.”
Are there any human studies that prove Phase 2 ™ effectiveness?
Yes. Human studies indicate that this natural starch blocker has the ability to inhibit starches found in foods from being broken down to simple sugar. This amylase inhibiting effect causes most starches to pass through the GI tract undigested thus causing a smaller increase in blood glucose levels within 15 to 80 minutes following intake of starchy carbohydrate foods. The following describes one of the studies performed on Phase 2.
November 20 - In vivo effectiveness of a starch absorption blocker in a double-blind placebo-controlled study with normal college-age subjects.
Joe A. Vinson, PhD and Donna M. Shuta, BS
Department of Chemistry
University of Scranton
Scranton, PA 18510
Inhibition of carbohydrate metabolism or absorption is one mechanism to reduce hyperglycemia in normal and especially in diabetic subjects. Another possible benefit is the decrease in calorie intake after eating carbohydrates for obesity and weight loss. In the 1980's there were several reports of in vitro and in vivo effectiveness of a natural starch blocker that worked by inactivating the enzyme amylase. We investigated this hypothesis with an initial pilot study. After this initial study with subjects who were physically active during the study, we did a second study to confirm the results. In this second study, again there was a double-blind placebo-controlled crossover trial with ten subjects (five males and five females aged 21 to 27) who participated with informed consent. After an overnight fast the subjects appeared in the morning and were given in a random fashion either
placebo consisting of 4 slices of white bread (60 g of carbohydrate), 42 g of soybean oil margarine, and 4 g of Sweet N'Low
experimental comprising the control plus 1.5 g of Phase 2™ (Pharmachem Laboratories).
The subjects rested between blood drawings. Plasma glucose was measured from blood sample drawn at baseline and every 15 minutes for 1 hour, then every 20 minutes for the second hour. Two subjects did not complete the study and 4 subjects were poor/non-absorbers as the area under the glucose-time curve was negative. Therefore the data of the remaining 4 subjects was used.
As expected the control bread produced an increase in glucose in the normal subjects that reached a broad peak after 45 minutes. The peak glucose for the Phase 2™ group occurred at 30 minutes. This dose of Phase 2™ produced a smaller increase than the control from 15 to 80 minutes, with an almost significant difference (p < 0.1) at 45 and 60 minutes. The glucose cleared from the plasma about 30 minutes earlier with the Phaseolamin™ compared to the control. The area under the plasma glucose-time curve (a measure of glucose absorption and metabolism) was 85% lower with the Phase 2™, p < 0.05. Thus only 15% of the glucose in the bread compared to the control found its way into the body in the presence of Phase 2™. These results show the effectiveness of the product in decreasing the absorption of glucose from complex carbohydrates from this group of subjects. |
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