Supports cardiovascular health*
Extensive clinical research has shown that niacin as nicotinic acid may promote a favorable balance of blood lipids. The form of niacin typically found in multivitamins and fortified foods is “nicotinamide,” which exhibits vitamin B3 activity but not necessarily the cardiovascular benefits seen in research that examined nicotinic acid. According to a report endorsed by the American Heart Association, nicotinic acid appears capable of modulating blood lipids in part by altering their synthesis and inhibiting the mobilization of free fatty acids.1
Extended-release formula decreases chance of “Skin Flushing”*
Real Niacin provides an 8-hour extended-release tablet that enables more people to access the health-supportive aspects of niacin with less chance of experiencing the uncomfortable skin flushing that commonly accompanies the unspecialized niacin in immediate-release (IR) forms of the vitamin. Release of the eicosanoid prostaglandin D2 from skin cells is believed to be behind the skin flushing that may occur with niacin use. This “prickly heat” phenomenon results in a sensation of warmth, reddening, and/or tingling anywhere from 15 to 120 minutes after consumption of a large dose, often felt on the head, neck, and shoulders for up to an hour. Although flushing is a non-allergic reaction producing no permanent harm to the body, it is the major reason for discontinued use of niacin—thereby preventing many individuals from experiencing the potential benefits of supplementation. When taken as directed, extended-release formulas similar to Real Niacin have been shown to decrease the potential of flushing.2, 3
Supports the maintenance of cognitive function with age*
Diets high in niacin have been associated with healthy cognitive function in the aging mind. This may in part be a result of niacin’s direct role in the regulation of healthy dendritic growth; dendrites are a class of neuronal cells that enable the brain to communicate electric signals to other parts of the brain and the body. Niacin is able to provide potent antioxidant activity to address the accumulation of free radicals in brain mitochondria, the powerhouse organelles within neurons. Niacin is important for many of the complex regulatory pathways utilized by the body to maintain health with age. The possible associations between niacin intake and the maintenance of healthy cognitive function with age were investigated through the examination of data from the massive Chicago Health and Aging Project (CHAD). The cognitive function in 3718 CHAD participants was assessed by four tests designed to measure mental attributes such as short and long term memory, intellectual ability, and motor control. Among the elderly participants who remained in good health during the 6-year study period, cognitive function was maintained at a 44% greater rate in individuals who had the highest dietary intake of niacin compared to those who consumed the lowest amount of niacin.4
Supports healthy metabolism and energy production within the body*
Niacin is rapidly absorbed by the cells lining the intestinal wall (enterocytes), where it is immediately converted to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in electron transfer (redox) reactions. The enterocytes use what NAD+ they need and send the rest to the liver as nicotinamide, the biochemical precursor to NAD+ and sister coenzyme nicotinamide adenine dinucleotide phosphate (NADP+). The two molecules NAD+ and NADP+ are involved in more than 500 enzymatic reactions and are especially important in metabolism and energy production. All of the human body’s cellular energy is synthesized through mitochondrial oxidative phosphorylation, the citric acid cycle, and cytosolic glycolysis: these pathways all require an adequate supply of NAD+ and NADP+. Since excess niacin is continually cleared from the body, dietary niacin must be regularly consumed to maintain the biochemical precursors needed to produce NAD+ and NADP+ throughout the day.5 Real Niacin supplies the body with niacin in a timed-release form that may support healthy metabolism and energy production throughout the day.
Maintain healthy cell cycles in response to reactive oxygen species*
Nicotinamide, the major liver metabolite of niacin is a robust regulator of cellular vitality in response to oxidative stress. It is important for the regulation of healthy cell cycles by controlling responses to both early membrane phosphatidylserine (PS) residues and preventing later genomic DNA degradation due to oxidative stress. PS residues are an important signaling mechanism used by the cell to sense extracellular oxidative damage; in-vitro experiments have demonstrated that nicotinamide modulates PS signaling, ultimately maintaining cell health and preventing DNA degradation in response to reactive oxygen species. The latest biochemical research is also bringing to light some complex cellular pathways through which nicotinamide impacts cellular inflammation and immune system function.6
1.NCEP, Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 2002. 106(25): p. 3143-421.
2.McKenney, J., New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med, 2004. 164(7): p. 697-705.
3.Guyton, J.R. and H.E. Bays, Safety considerations with niacin therapy. Am J Cardiol, 2007. 99(6A): p. S22-31.
4.Morris, M.C., et al., Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline. J Neurol Neurosurg Psychiatry, 2004. 75(8): p. 1093-9.
5.Depeint, F., et al., Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact, 2006. 163(1-2): p. 94-112.
6.Maiese, K., et al., The vitamin nicotinamide: translating nutrition into clinical care. Molecules, 2009. 14(9): p. 3446-85.