Trans-resveratrol [from Polygonum cuspidatum extract (root) and whole red grape (Vitis vinifera) extract]
Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Wild Blueberry (Vaccinium angustifolium), and Polygonum cuspidatum extract blend [supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)]
Quercetin (as quercetin dihydrate)
Trans-Pterostilbene (as pure Pterospan™ and SMART™† pterostilbene)
Fisetin [from (Rhus succedanea L.) extract (stem)]
**Daily value not established. †Same material as research trials.
Other Ingredients: vegetable cellulose (capsule), silica, vegetable stearate.
Contains no: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Directions: Take one capsule daily with or without food, or as recommended by a healthcare practitioner.
Caution: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
Pterospan™ (Pure Pterostilbene) and SMART™ are trademarks of Pharma Science Nutrients, Inc., and are used here under license. All rights reserved worldwide.
Optimized Resveratrol with Synergistic Grape-Berry Actives includes fisetin, to enhance resveratrol’s beneficial action. The formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources.
Findings from published scientific literature indicate that resveratrol may be the most effective plant extract for maintaining optimal health and promoting longevity.1 Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera in response to attack by molds.
Life Extension® has gone to great lengths to identify compounds that simulate calorie restriction’s ability to trigger youthful gene expression—the process by which genes transmit signals that slow certain aspects of aging. For example, previous research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals. A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent “longevity gene” activators that work in synergy with resveratrol.
Life Extension's Optimized Resveratrol now features fisetin, a little-known flavonoid which is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction2—without significant dietary modification. In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.3
Most abundant in strawberries, fisetin has the power to “switch on” powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.2 It also supports aging neurons in the presence of oxidative stress.4-6 Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown3 and extending its effects.
References 1. Clin Interv Aging. 2008;3(2):331-9. 2. Nature. 2004 Aug 5;430(7000):686-9. 3. Xenobiotica. 2000 Sep;30(9):857-66 4. Genes Nutr. 2009 Sep 10. 5. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73. 6. Brain Res. 2007 Oct 10;1173:117-25.
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The majority of the product information has been reprinted from the manufacturer.