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SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW® SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.*
Read More about SAMe from Your Health Professor
Clinical Trial Supports Efficacy of NOW® SAMe for OA of the Knee
SAMe (S-adenosylmethionine or S-Adenosyl-L-Methionine) is a naturally occurring compound found in all human tissue and organs. It is a building block necessary for the production of many compounds produced by your body, and is used in over 35 different biochemical reactions. SAMe actually donates a part of itself to form these new compounds through a process called methylation, or transmethylation. SAMe is one of the few dietary supplements on the market today that combines the benefits of several nutrients into one, because the body uses the substances produced from SAMe for numerous body processes, including detoxification.
SAMe is a very safe dietary supplement. Minor side effects include nausea and gastrointestinal irritation, probably due to its sulfur content. But these were only noted at very high doses (1200-1600mg), and the symptoms diminished with continued use. Persons suffering from manic depression (bipolar disorder) should not take SAMe without prior consultation with their physician. If you experience any of these symptoms, it may not be the right supplement for you. The mineral Sulfur is not related to sulfa drugs or allergies related to sulfa drugs.
SAMe in its pure form as found in human cells has a very short life span and is rapidly metabolized into other necessary compounds as needed, which is good! However, this natural form does not allow for the production of a stable, effective dietary supplement. It took scientists years to come up with a way to stabilize SAMe so it could be manufactured as a dietary supplement. It was finally discovered that SAMe (S-Adenosyl-L-Methionine) must be manufactured in a stable salt form (for example, as S-Adenosyl-L-Methionine Disulfate Tosylate) to prevent rapid degradation. In this form, you will actually get 200mg of SAMe compounded in a stable form. However, only half of this 200mg is pure SAMe (S-Adenosyl-L-Methionine). Please note that this salt is not a significant source of sodium.
Because of the nature of SAMe, NOW takes special precautions when packaging this product. Extensive stability testing was performed in order to create this uniquely stabilized product. We bottle SAMe in amber glass bottles to keep light exposure to a minimum, and keep SAMe products refrigerated in our plant until shipping. It is not necessary to keep SAMe refrigerated after purchase, but it will extend the shelf life of the product. The bottle should be kept closed between uses, away from excessive heat and moisture.
Because SAMe is a natural product, there can be variations in color, usually ranging from white to pale yellow or tan. This is normal and does not affect the quality of the product. You may also notice a difference in tablet size between different potencies. SAMe is available in 100mg, 200mg, and 400mg enteric-coated tablets, all coming in different sizes.
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*Statements on this site have not been evaluated by the Food and Drug Administration. Products on this site are not intended to diagnose, treat, cure, or prevent any disease.
Prices are subject to change at anytime and without notice. The majority of the product information has been reprinted from the manufacturer.
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| Orders Up to $75 | Orders $75.01 to $100 | Order Over $100 | Order Weight | ||
|---|---|---|---|---|---|
| Ground | $2.95 | Free | Free | Any weight ** |   |
| 2nd Day Air | $15.95 | $15.95 | $10.00 | 5 lbs and under*** | |
| Next Day Air | $25.95 | $25.95 | $20.00 | 2 lbs and under*** | |
Orders placed by 12:00pm CST will usually ship that day (Mon-Fri). Our same day fill rate is currently running at over 90%.
**Ground
Most orders shipped to AK, HI, PR or APO and PO Box addresses will go US Priority Mail and may require additional shipping costs, depending on weight. In that case we will email the customer for approval of those additional charges before applying them. We ship with UPS, Spee-Dee Delivery (serving select areas in the midwest), US Priority Mail and US First Class Mail. Packages shipped to a business address are appreciated. Orders received by 12pm central standard time will usually ship on that day. We are currently shipping only within the United States and Puerto Rico.
***2nd Day and Next Day
Our flat rate 2nd Day (up to 5 pounds) and Next Day service (up to 2 pounds) does not include orders shipped to a PO Box or an APO address. It also does not include orders shipped to AK, HI or PR. If you know the order will be overweight or you would like your order shipped express to AK, HI or PR, please call us for a quote at 1-800-418-4842. If you are not sure, just submit the order and we will contact you if it weighs more.
Normal business hours are Monday - Friday 8:30-3:30pm CST. We DO NOT ship on Saturdays, Sundays or the following holidays... New Year's Day, Martin Luther King Jr. Birthday (Post Office Closed), Washington's Birthday (Post Office Closed), Memorial Day, Independence Day, Labor Day, Columbus Day (Post Office Closed), Veterans Day (Post Office Closed), Thanksgiving, Christmas Eve and Christmas Day.
All orders shipped within Minnesota will be charged a 6.875% sales tax, all other orders will not be taxed.
*Please Note* Please be careful to give us your correct address. You will be charged a fee of $12.00 for any order that is either incorrectly addressed or re-routed due to customer error. We generate our shipping labels from the information the customer provides us, so if you give us an incorrect or incomplete address (incorrect zip code, missing apartment/suite/office number, etc.), you will be charged the $12.00 fee. We have to charge the $12.00 for incorrect delivery information, because that is what UPS charges us.
If you would like your package left at your house without a signature, please indicate that when you order. If you do instruct us to deliver the package without having someone sign for it (ex. "Please leave on front porch"), then we cannot be responsible for missing packages that can be tracked to your delivery address.
Guaranteed Ground Time-In-Transit Map for UPS Shipments:
