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Brand: Life Extension     Categories: Depression / SAMe


 

SAMe 400mg

 

Item#

Brand

Name

Size

Form

Retail

Price

 

399

Life Extension

SAMe 400mg

20

Tablet

$35.00

$26.25

 

400

Life Extension

SAMe 200mg

20

Tablet

$18.95

$14.21

 

 



SAMe 400mg

SAMe 400mg  20  Tablet


Supplement Facts

Serving Size: 1 Tablet

Amount per
serving
% Daily*
Value

S-Adenosyl-Methionine

400

mg

**

**Daily value not established.


Other Ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre.


Contains: soybeans and yeast.


Contains no:
milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, colors, flavors, or preservatives.


Directions:
Take one (1) tablet two to three times daily in divided doses morning, midday, and late afternoon, or as recommended by a healthcare practitioner. Take folic acid, vitamins B12 and B6 when using SAMe. Taking this product with food may prevent gastrointestinal upset.


Caution:
SAMe should not be taken by those diagnosed with bipolar disorder.

 


SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:


Methylation (contributing methyl groups to activate certain molecules)16,17

The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)18-20

Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)21-23


SAMe occurs naturally in the body; it is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.24 SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.


SAMe levels may become depleted from sickness and age. Supplementation of the co-factors folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.16,17,19,22-23,25


In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Their findings show the efficacy of SAMe in helping maintain stable mood and joint function, without any side effects.26 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.18,27-32 In addition, SAMe has multi-modal mechanisms of action that are used throughout the body, and especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage.


References

 

 


 






 
 

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*Statements on this site have not been evaluated by the Food and Drug Administration. 
Products on this site are not intended to diagnose, treat, cure, or prevent any disease. 
Prices are subject to change at anytime and without notice. 
The majority of the product information has been reprinted from the manufacturer.